To minimize radiation exposure, a person with AT should be following specific guidelines. As their cells are highly sensitive to radiation, they should avoid exposure to ionizing. They should also avoid radiotherapy and radiomimetic radiotherapeutic agents. In addition, they should not be treated aggressively, and should not undergo a heightened surveillance in comparison to the general population.
Variations of at Indonesian
There are many variations of the word at that are commonly used by Indonesians. Indonesian is similar to English in its word order, which allows for great flexibility. Languages like Japanese, Korean and Korean use verbs to end clauses. Furthermore, Indonesian does away with gender and grammatical cases.
In Indonesian, the term at can be used for one's age. It can also be used as a pronoun because it has a consonant (a). This pronoun can signify a variety of gendered positions, such as solidarity or epistemic authority. This article examines how at is used to construct heterogeneous selves among young Indonesians.
Five vowels can be found in Indonesian. These vowels can be distinguished with diacritic. The mid-front vowel of Indonesian /e/ is pronounced differently from the mid-central vowel of /a/. The last syllable of Indonesian is stressed. But the glottal end is represented by an "apostrophe".
The ATM gene regulates cell divide after DNA damage
ATM plays a role in DNA damage response and maintaining genome integrity. It also regulates autophagy (mitophagy), mitophagy (pexophagy), and other processes that maintain cellular equilibrium in response to ROS.
The ATM protein has multiple domains, including a serine/threonine kinase (STK) domain that is essential for full activation. It also has multiple autophosphorylation locations that can impact its function. The N terminal contains a Nuclear Localization Signal. (NLS), which facilitates nuclear translocation. The putative nucleotide zipper motif (N-terminus) is important for dimerization. The substrate binding is dependent on the C-terminus, which has autophosphorylation points.
The ATM gene recruits many DNA repair and signalling proteins once activated. One-stranded DNA molecules bind to DNA and signal replication stress when the cell is damaged by DNA. This activates the ATM kinase and the p300/CBP activators. This delays cell entry into S-phase and stops unrepaired DNA mutants from being passed to daughter cells.
ATM can cause leukemia or lymphoma
Study of ATM-caused leukemia and lymphomia has shown that the ATM gene plays a role in these diseases. AT patients have frequent mutations in the ATM gene. The mutations are located in the 11q23 region. Researchers found that between three and six percent (three to six%) of AT patients had 11q23 translocations. This usually involves the MLL gene. ATM mutations may also be present in sporadic cases of lymphomas.
Ataxia telangiectasia (AT) is an autosomal recessive neurodegenerative disorder that is characterized by an increased risk of cancer. Nearly ten per cent of patients with ATM mutations experience lymphoid malignancies. They are mainly B/T-cell cancer.